Projects

Cataract surgery

In progress

Performance of two non-diffractive intraocular lenses with extended depth of vision set for mini-monovision.

In progress

Capsular bag performance of two hydrophobic intraocular lenses of different design

In progress

Safety and Efficacy of the complementary fixOflex intraocular implant for cataract surgery

In progress

Intraindividual comparison oft two non-diffractive extended depth of focus intraocular lenses set for emmetropia.

In progress

Difference in visual performance of a refractive extended depth of focus intraocular lens in an emmetropic and monovision modality.. The aim of the study is to compare the visual performance of a new non-diffractive intraocular lens with extended depth of vision set for emmetropia (targeted closest to 0 D) or monovision (targeted closest to -0.75 D).

In progress

Myopred: Influence of posterior vitreous detachment on retinal detachment after lens surgery in myopic eyes. In most cases the functional and clinical outcomes of phacoemulsification with implantation of posterior chamber lenses are excellent and high patient and clinician satisfaction has been reported. However, there is a risk of developing complications such as pseudophakic retinal detachment (PRD) after surgery. Especially, myopic patients have an increased risk of PRD compared with the general population. The aim of the study is to document the pre-operative presence and/or post-operative development of PVD and to assess its influence on the incidence of PRD in myopic patients in a time period of three and five years after lens surgery.

In progress

Tilt, centration and stability of secondary intraocular lenses with no capsular support.. The aim of the study is to detect the difference in IOL centration, tilt and wobble in secondary IOLs.

OTHER STUDIES

In progress

Evaluation of the grasp site after peeling of epiretinal membranes with different ILM forceps – a prospective randomized study

In progress

Multicentric evaluation of Best Corrected Visual Acuity of the XEN implant versus classic Trabeculectomy in Open Angle Glaucoma subjects

In progress

Automated deep learning for detection of epithelial basement membrane dystrophy using optical coherence tomography and longitudinal reproducibility of disease characteristics

In progress

Evaluation of micromorphological structure of idiopathic epiretinal membranes for initiation of membrane peeling

In progress

Pattern analysis of sectional corneal images in patients with microbial keratitis by artificial intelligence using anterior segment optical coherence images and verification by corneal smear or scrape: A Pilot study.

In progress

Comparison between swept source OCT keratometry and Scheimpflug respectively spectral domain OCT combined with Placido disc keratometry.

In progress

Pseudophakic eyes implanted with different presbyopia-correcting IOL designs.

In progress

The effect of caffeine consumption on cataract formation after pars plana vitrectomy: a comparative study.

In progress

Risk factors for re-ablatio after primary vitrectomy for rhegmatogenous retinal detachment. The aim of the study is to find out which risk factors are associated with an increased incidence of postoperative retinal re-ablatio.

In progress

Correlation of functional vision parameters and dysfunctional lens syndrome using anterior segment optical coherence tomography: a pilot study.. The aim of the study is to image early stages of DLS and to correlate them with functional impairment.

In progress

Brillouin scanning in cataractous eyes, corneal diseases, glaucoma and myopia. The aim of the studies is to measure lenticular and corneal biomechanical properties of patients with cataract, corneal diseases, glaucoma and myopia via Brillouin microscopy.

COMPLETED STUDIES

Completed

Pharmacokinetics of caffeine in epiretinal membranes after oral intake: a pilot study

Completed

ILM flap transposition versus ILM Peeling for macular holes: a pilot study

Completed

Intraretinal cystoid changes after vitrectomy with membrane peeling

Completed

Comparison between two wide-field imaging systems on the extent of retinal periphery area viewing – Short title: comparison of wield-field imaging

Completed

Cultivation of hyalocytes from ILM and ERM samples: a pilot study

Completed

In vitro reversal of cataract: A pilot study

Completed

Swept Source OCT biometry: Feasibility study to evaluate the applicability of the “Cataract and Refractive Imaging Platform” for measurements in different ocular conditions.

Completed

Artisan IOL: Visual acuity outcome after implantation of an iris-fixated and scleral fixated IOL in eyes with no capsule support

Completed

OCT Catgrading: Cataract quantification using swept source-based optical coherence tomography: a pilot study

Completed

Low Asti: Assessing the astigmatism reducing effect with toric IOLs in eyes with low astigmatism

Completed

Rotational stability of the TECNIS Eyhance toric II IOL

Completed

Predicting the lens capsular bag size using pre-operative biometry

Completed

Role of postoperative lubrication in preventing dry eye after cataract surgery

Completed

Anterior chamber depth (ACD) variability between the Clareon and Acrysof IOL: a randomised trial

Completed

ArcScan: To assess if using a high resolution immersion ultrasound measurement improves intraocular lens power calculation

Completed

Computer-based tutorial as supportive means to enhance quality and efficiency of the informed consent process for cataract surgery in Turkish or Serbian speaking patients

Completed

Neuromaster: Pain perception and discomfort of second eye cataract surgery in comparison with the first eye in correlation with perioperative stress

Completed

Evaluation of reading quality in three different patient groups (Extended Range Of Vision vs minimonovision vs single focus distance vision)

Completed

Evaluation of intraoperative capsular polishing on lens epithelial cells and the development of posterior capsule opacification

Completed

Keratoconus: Using a keratoconus registry data base and evaluation of the German version of a validated keratoconus questionnaire (KORQ)

Completed

FTIR: Fourier Transformed Infrared Microspectroscopy of epiretinal membranes and internal limiting membranes

Completed

Prevention of experimental ultraviolet induced apoptosis in explanted human lens epithelial cells enriched with caffeine: a pilot study

Completed

Evaluation of axial length changes between pre and postoperative measurements – A pilot study

Completed

IFIS II: Effect of the selective alpha 1A receptor antagonist tamsulosin on the thickness of the iris dilator muscle

Completed

Effekt of air-tamponade on intraretinal cystoid changes after 23G ppV with membrane peeling

Completed

LUCIA II: Prospective clinical trial to compare the postoperative horizontal position stability of the CT LUCIA 611P and the CT ASPHINA 409 MP

Completed

IFIS I: Predicting the severity of IFIS before surgery

Completed

Rhexis Protection Shield: Protecting the corneal endothelium during cataract surgery using the anterior capsule bag: a prospective randomised double-masked study

Completed

Toric IOL: Rotational Stability of the Blue Light-absorbing Hydrophobic Acrylic Posterior Chamber Single Piece Intraocular Lens (Model YST0.00)

Completed

Conjunctivitis: A Phase 3, multi-center, randomized, double-masked study to evaluate the clinical efficacy and safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension compared to PVP-Iodine and Placebo in the treatment of adenoviral and bacterial Conjunctivitis

Completed

Caffeine and lens: Pharmacokinetics of caffeine in the lens after oral intake: a pilot study

Completed

Formycon: Efficacy and safety of the biosimilar ranibizumab FYB201 in comparison to lucentis in patients with neovascular age-related macular degeneration (Columbus-AMD)

Completed

PLSG: Partial least squares regression modelling for glaucoma detection using retinal nerve fiber layer, ganglion cell layer and visual field data

Completed

Glaukom MP3: Follow up measurements for partial least squares regression modelling for glaucoma detection using retinal nerve fiber layer, ganglion cell layer and visual field data

Completed

Effect of Cataract extraction on retinal sensitivity measurements using microperimetry (Micro Perimeter 3) – Pilotstudy

Completed

Rotational stability of the Toric Tecnis one-piece IOL: a pilot study

Completed

Rotational stability of the single-piece acrylic IDEA 613 XC® IOL: a pilot study

Completed

Corneal changes induced by limbal relaxing incision and opposite clear corneal incision

Completed

Comparison of toric IOL implantation and opposite clear corneal incision during cataract surgery to correct corneal astigmatism

Completed

Evaluation of an intra-operative tracking system for toric IOL positioning

Completed

Impact of incision size and architecture on wound stability and astigmatism in cataract surgery: an exploratory study

Completed

Methods to manage intra-operative floppy-iris syndrome and poor pupil dilation in cataract surgery: a randomised study

Completed

Efficacy and safety assessment of intracameral T2380 (fixed combination of lidocaine, phenylephrine and tropicamide) for mydriasis and anaesthesia in phacoemulsification cataract surgery

Completed

Safety and efficacy of a novel hydrophobic acrylic IOL – iPure: a randomised study

Completed

Reducing the use of reading spectacles in pseudophakic patients – „Motivation Study“

Completed

Impact of rotating lens cortex fragments on the endothelial cell outcome after phacoemulsification

Completed

Predictability of the IOL position using an intra-operative OCT

Completed

Capsule bag performance of a novel single-piece acrylic IOL – HOYA AF-1 NY-60

Completed

Aqueous flare of a hydrophobic acrylic single-piece open-loop IOL with modified material surface properties

Completed

Validation of the German version of a 9-item questionnaire to evaluate patients‘ satisfaction undergoing cataract surgery

Completed

Computer-based tutorial as supportive means to enhance quality and efficiency of the informed consent process for cataract surgery

Completed

„The human retinal autofocus“ – Choroidal and scleral thickness changes in response to defocus and elevation of intraocular pressure in myopia

Completed

Two center trial with medical university Graz: Influence of combined vitrectomy plus cataract surgery on postoperative intraocular lens position: a prospective bilateral comparison

Completed

TILT: Tilt of the intraocular lens in patients undergoing combined phacoemulsification and vitrectomy with airtamponade

Completed

Trifocal: Comparison of visual performance of 2 diffractive trifocal intraocular lenses: a randomised controlled trial

Completed

Eplerenon: A randomized, double-masked, placebo controlled study of the beneficial effects of eplerenone on central serous chorioretinopathy

Completed

Effect of an intraocular lens (IOL) with enhanced peripheral vision on gait performance: a pilot study

Completed

Assessment of reading performance in patients with AcrySof® IQ Vivity toric or non-toric® vs monofocal AcrySof IQ toric or non-toric IOL

Completed

Comparison of three swept-source optical coherence biometry devices in long and short eyes

Completed

Effectiveness of Periocular drug Injection in CATaract surgery

Completed

Cataract Online Refraction Evaluation: A Multi Center Randomized Controlled Trial (CORE-RCT)

Completed

Negative Dysphotopsia: Defining and quantifying negative dysphotopsia and characterization and causative factors of negative dysphotopsia

Completed

Oculentis (Multifokal vs Monofokal): Comparison between bilateral low-add multifocal intraocular lenses and monofocal intraocular lenses: a randomised trial

Completed

Incidence of Epiretinal Membranes after Phacoemulsification with Implantation of an Intraocular Lens – The ERM Phaco Trial

Completed

ERM: Visual acuity and optical coherence tomography one year after Membrane Peeling

Completed

ILM Flap: Visual acuity and retinal morphology one year after ILM-flap transposition for macular hole repair

Completed

Intra-OP OCT: Using an intra-operative optical coherence tomography device for predicting the intraocular lens position. Since the introduction of optical biometry (IOLMaster, Carl Zeiss Meditec AG, Jena, Germany) as a reliable non-contact measurement of the axial eye length the influence of the error of axial length measurement on the refractive error decreased from over 50% (when measured with applanation ultrasound) to 36%. These results show that the estimation of the post-operative intra-ocular lens (IOL) position and therefore the estimated anterior chamber depth (ACD) is presently the main source of error (35% 3 to 42% 2) in IOL power calculation and therefore for the refractive outcome of the patients after cataract surgery. The aim of this study is to observe whether the number of successful intra-operative scans of the lens capsule position after cataract removal can be increased to a minimum of 98% and whether the refractive outcome could be improved by using both pre- and intra-operative measurements for IOL power calculations.

Completed

Swept Source OCT biometry: Feasibility study to evaluate the applicability of the “Cataract and Refractive Imaging Platform” for measurements in different ocular conditions.. The Heidelberg Engineering “Cataract and refractive Imaging Platform” is a non-CE marked Swept-Source OCT ophthalmological imaging and measurement device. Analyzed metrics include anterior and posterior corneal topography, corneal pachymetry, anterior chamber depth and –angle, lens thickness, axial length, pupil diameter and corneal diameter. This study evaluates the feasibility of the Cataract and refractive Imaging Platform’s technology in terms of acquiring OCT images of eyes with certain ocular conditions (normal eyes, corneal irregularities, dense cataract, pseudophakia, macula pathologies, long eyes) that are appropriate for later metric assessment. Secondary, repeatability and reproducibility of results will be looked at.

Completed

Reading performance: Reading analysis in ophthalmological patients – Pilotstudy. Reading is a complex function. It requires a proper retinal image that is received by the brain. Reading speed slows down when letters are blurred, or do not have enough contrast or luminance or when binocular fusion is hampered or due to scotoma. Hence, it is obvious that reading ability is reduced in patients with various ocular diseases. The present study is designed to investigate the reading parameters and fixation behavior in patients with different ocular diseases (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane) and healthy subjects. In addition, fixation analysis and retinal sensitivity measurements will be done with the microperimeter (MP3, Nidek, Japan) in each subject.